医学生物化学与分子生物学系 研究员
职称：研究员
学科专业：生物化学和分子生物学
研究方向：肿瘤代谢重编程的分子病理机制及应对策略研究
行政职务：副院长
电子邮箱：[email protected]
个人介绍：2008年在中国科学技术大学获得博士学位，2008-2012年在美国埃默里大学（EMORY UNIVERSITY）血液病和临床肿瘤学系完成博士后研究工作并于2012年起任讲师，2015年至2018年受聘于埃默里大学医学院任助理教授（Tenure Track)，2018年全职回国工作。主要从事肿瘤和白血病细胞代谢重编程的分子机制研究和针对新型靶点的小分子药物研发工作。以通讯作者和第一作者在Molecular Cell (2011, 2014a, 2014b, 2015, 2016), Nature Cell Biology (2015), Cell Metabolism (2017), Signal Transduction and Targeted Therapy (2020), European Respiratory Journal (2022)，Cancer Communications (2021), Frontiers in Pharmacology (2021) 等期刊上发表学术论文。研究工作先后获得美国癌症协会(American Cancer Society, ACS)培养计划和美国癌症杰出研究专项基金(Specialized Programs of Research Excellence, SPORE)培养计划，国家自然科学基金，广东省自然科学基金，广东省重大人才工程高层次人才引进项目的资助。
2004.02-2008.06中国科学技术大学，博士
2018.06-至今，金沙娱乐城在线门户网站 ，研究员，副院长。
2015.01-2018.06，美国埃默里大学医学院放射肿瘤学系，助理教授（Tenure Track)。
2012.06-2015.01，美国埃默里大学医学院血液病和医学肿瘤学系，讲师。
2008.10-2012.06，美国埃默里大学医学院血液病与医学肿瘤学系，博士后研究员。
通讯作者文章：
[1]Xie, X., Wu, F., Tian, J., Liu, Z., He, H., Bao, D., Li, G., Li, H., Chen, J., Lai, Y., Chen, Z., Fan, J.*, Chen, G.*, Lai, C.*, 2022. Pyrocatechol Alleviates Cisplatin-Induced Acute Kidney Injury by Inhibiting ROS Production. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2022, 2158644. //doi.org/10.1155/2022/2158644.（IF: 7.3）.
[2]Jia, H., Liu, C., Li, D., Huang, Q., Liu, D., Zhang, Y., Ye, C., Zhou, D., Wang, Y., Tan, Y., Li, K., Lin, F., Zhang, HQ, Lin, J., Xu, Y., Liu, J., Zeng, Q., Hong, J., Chen, G., Zhang, H, Zheng, L., Deng, X., Ke, C., Gao, Y.*, Fan, J.*, Di, B.*, Liang, H.*, 2022. Metabolomic analyses reveal new stage-specific features of COVID-19. EUROPEAN RESPIRATORY JOURNAL 59(2): 2100284. //doi.org/10.1183/13993003.00284-2021.（IF:.33.8，1区 TOP期刊）.
[3]Yan, L., Tan, Y., Chen, G., Fan, J.*, Zhang, J.*, 2021b. Harnessing Metabolic Reprogramming to Improve Cancer Immunotherapy. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 22, 10268. //doi.org/10.3390/ijms221910268.（IF:6.2，2区 TOP期刊）.
[4]Yan, L., Liu, Y., Ma, X., Hou, D., Zhang, Y., Sun, Y., Shi, S., Forouzanfar, T., Lin, H.*, Fan, J.*, Wu, G.*, 2021a. Triclabendazole Induces Pyroptosis by Activating Caspase-3 to Cleave GSDME in Breast Cancer Cells. FRONTIERS IN PHARMACOLOGY 12: 670081. //doi.org/10.3389/fphar.2021.670081. （IF:5.8，2区 TOP期刊）.
[5]Tian, L., Chen, C., Guo, Y., Zhang, F., Mi, J., Feng, Q., Lin, S., Xi, N., Tian, J., Yu, L., Chen, Y., Cao, M., Lai, C.*, Fan, J.*, Zhang, Y.*, Chen, G.*, 2021. mTORC2 regulates ribonucleotide reductase to promote DNA replication and gemcitabine resistance in non-small cell lung cancer. NEOPLASIA. 23, 643–652. //doi.org/10.1016/j.neo.2021.05.007.（F:6.3，2区）.
[6]Tian, T., Fan, J.*, Elf, S.*, 2021. Metabolon: a novel cellular structure that regulates specific metabolic pathways. CANCER COMMUNICATIONS 41, 439–441. //doi.org/10.1002/cac2.12154.（IF:15.2，1区 TOP期刊）.
[7]Di, B., Jia, H., Luo, O., Lin, F., Li, K., Zhang, Y., Wang, H., Liang*, H., Fan, J.*, Yang, Z.*, 2020. Identification and validation of predictive factors for progression to severe COVID-19 pneumonia by proteomics. SIGNAL TRANSDUCTION AND TARGETED THERAPY 5, 217 (2020). //doi.org/10.1038/s41392-020-00333-1.（IF:38，1区 TOP期刊）.
[8]Zhang, H., Quan, Q., Zhang, M., Zhang, N., Zhang, W., Zhan, M., Xu, W., Lu, L.*, Fan, J.*, Wang, Q.*, 2020b. Occurrence of bisphenol A and its alternatives in paired urine and indoor dust from Chinese university students: Implications for human exposure. CHEMOSPHERE 247: 125987. //doi.org/10.1016/j.chemosphere.2020.125987.（IF:8.9，2区 TOP期刊）.
[9]Zhang, H., Quan, Q., Li, X., Sun, W., Zhu, K., Wang, X., Sun, X., Zhan, M., Xu, W., Lu, L.*, Fan, J.*, Gao, Y.*, 2020a. Occurrence of parabens and their metabolites in the paired urine and blood samples from Chinese university students: Implications on human exposure. ENVIRONMENTAL RESEARCH 183: 109288. //doi.org/10.1016/j.envres.2020.109288. （IF:8.4，2区 TOP期刊）.
[10]Xia, S., Lin, R., Jin, L., Zhao, L., Kang, H., Pan, Y., Liu, S., Qian, G., Qian, Z., Konstantakou, E., Zhang, B., Dong, J., Chung, Y., Abdel-Wahab, O., Merghoub, T., Zhou, L., Kudchadkar, R., Lawson, D., Khoury, H., Khuri, F., Boise, L., Lonial, S., Lee, B., Pollack, B., Arbiser, J., Fan, J.*, Lei, Q.*, Chen, J.*, 2017. Prevention of Dietary-Fat-Fueled Ketogenesis Attenuates BRAF V600E Tumor Growth. CELL METABOLISM 25, 358–373. //doi.org/10.1016/j.cmet.2016.12.010.（IF:31，1区 TOP期刊）.
[11]Lin, R.-T., Elf, S., Shan, C., Kang, H.-B., Shan, C., Kang, H.-B., Zhou, L., Hitosugi, T., Zhang, L., Zhang, S., Seo, J.H, Xie, J., Tucker, M., Gu, T.-L., Sudderth, J.A., Jiang,L., DeBerardinis R.J., Wu, S., Li, Y., Mao, H., Chen, Z.G., Hurwitz,S.J., Lonial, S., Arellano, M., Khoury, H.J., Khuri, F.R., Lee, B.H., Lei, Q.-Y., Brat, D.J., Ye, K., Boggon, T.J., He, C., Kang, S. *, Fan, J. *, and Chen, J*. 2015. 6-phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumor growth by inhibiting LKB1-AMPK signaling. Nature Cell Biology. 17, 1484–1496 (2015). doi:10.1038/ncb3255.（IF:28，1区 TOP期刊）.
[12]Shan, C., Kang, H.-B., Elf, S., Xie, J., Gu, T.-L., Aguiar Mike, Scott Lonning, Hitosugi, T., Chung T-W, Martha Arellano , Khoury, H.J., Khuri, F.R., Shin, D.M., Boggon, T. and Fan, J.* 2014.Tyr-94 Phosphorylation Inhibits Pyruvate Dehydrogenase Phosphatase 1 and Promotes Tumor Growth. J. Biol. Chem. 2014, 289:21413-21422. doi: 10.1074/jbc.M114.581124.（IF:4.1，2区 TOP期刊）.
[13]Shan, C., Elf, S., Ji, Q., Kang, H.-B., Zhou, L., Hitosugi, T., Zhang, L., Seo, J.H., Xie, J., Tucker, M., Gu, T.-L., Sudderth, J.A., DeBerardinis R.J., Wu, S., Li, Y., Mao, H., Chen, P., Lonial, S., Arellano, M., Khoury, H.J., Khuri, F.R., Lee, B.H., Brat, D.J., Ye, K., Boggon, T.J., He, C., Kang, S., Fan, J. *, and Chen, J*. 2014. Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth. Molecular Cell 21; 55(4):552-65. doi: 10.1016/j.molcel.2014.06.020.（IF:19.3，1区 TOP期刊）
第一作者文章：
[1]范骏, 翻译后修饰与肿瘤代谢重编程, 中山大学学报(医学科学版), 2022, 43(02): 161-172. (特邀综述) （中文核心期刊）
[2]Fan, J., Lin, R., Xia, S., Chen, D., Elf, S., Liu, S., Pan, Y., Xu, H., Shan, C., Zhou,L., Lei,Q., Li,Y., Mao, H., Lee, B.H., Gaddh, M., Arellano, M.L., Khoury, H.J., Khuri, F.R., Gaddh, M., Doetsch, P.W., Lonial, S., Boggon, T.J., Curran, W.J. and Chen, J*. 2016. Tetrameric Acetyl-CoA Acetyltransferase 1 Is Important for Tumor growth. Molecular Cell 2016 Dec 1;64(5):859-874. doi: 10.1016/j.molcel.2016.10.014.（IF:19.3）.
[3]Fan, J., Shan, C., Kang, H.-B.*, Elf, S., Xie, J., Tucker, M., Gu, T.-L., Aguiar, M., Lonning, S., Chen, H., Mohannadi, M., Britton, L.-M. P., Garcia, B.A., Aleckovic, M., Kang, Y., Kaluz, S., Devi, N., Van Meir, E., Hitosugi, T., Seo, J.H., Lonial, S., Gaddh, M., Arellano, M., Khoury, H.J., Khuri, F.R., Boggon, T.J., Kang, S., and Chen, J. 2013. Tyr-phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate pyruvate dehydrogenase complex. Molecular Cell 2014 20;53(4):534-48. doi: 10.1016/j.molcel.2013.12.026.（IF:19.3）.
[4]Kang, H.-B. *, Fan, J. *, Lin, R.-T.*, Elf, S., Ji, Q., Seo, J.H., Arbiser, J., Cohen, C Brat, D, Miziorko, H.M., Abdel-Wahab, O., Merghoub, T., Fröhling, S., Scholl, C., Tamayo, P., Barbie, D.A., Lonial, S., Khoury, H.J., Khuri, F.R., Lee, B.H., He, C., Kang, S., and Chen, J. 2015. Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling. Molecular Cell 2015 6;59(3):345-358. doi:10.1016/j.molcel.2015.05.037.（IF:19.3）
[5]Fan, J., Shan, C., Kang, H.-B., Elf, S., Hitosugi, T., Xie, J., Tucker, M., Gu, T.-L., Khoury, H.J., Khuri, F.R., Lee, B.H., Boggon, T.J., and Chen, J.* 2014. Tyr-301 phosphorylation inhibits pyruvate dehydrogenase by blocking substrate binding, and promotes the Warburg effect. J. Biol. Chem. 2015 6;59(3):345-358. doi:10.1074/jbc.M114.593970. （IF:4.125）
[6]Hitosugi, T.*, Fan, J.*, Chung, T.W.*, Lythgoe, K., Wang, X., Xie, J., Ge, Q., Gu, T.-L., Polakiewicz, R.D., Roesel, J.L., Chen, Z., Boggon, T.J., Lonial, S., Fu, H., Khuri, F.R., Kang, S., and Chen, J. 2011, Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism. Molecular Cell 2011 23;44(6):864-77.（IF:19.3）
[7]Fan, J., Hitosugi, T., Chung, T.W., Lythgoe, K., Wang, X., Xie, J., Ge, Q., Gu, T.-L., Polakiewicz, R.D., Roesel, J.L., Chen, Z., Boggon, T.J., Lonial, S., Khuri, F.R., Kang, S., and Chen, J. 2011. Tyrosine Phosphorylation of Lactate Dehydrogenase A Is Important for NADH/NAD+ Redox Homeostasis in Cancer Cells. Mol. Cell. Biol. 2011 31(24):4938-50. (Selected as a Spotlight Article by Editors).（IF:4.398）
[8]Fan, J., Ren, H-G, Fei, E-K, Jia, N-L, Ying, Z., Jiang, P., Wu, M. Wang, G-H DJ-1(K130R), the sumoylation-deficient mutant fails to decrease Bax. 2008. FEBS Letters Apr2;582(7):1151-6.（IF:3.623）
[9]Fan, J., Ren, H.-G., Jia, N.-L., Fei, E.-K., Zhou, T., Jiang, P., Wu, M. Wang, G.-H, DJ-1 decreases Bax expression through repressing p53 transcriptional activity. J. Biol. Chem (2008) Feb 15; 283(7):4022-30.（IF:4.125）
参与发表论文：
[1]李佳琪,孙勇,李乐,等. PDHA1促进三阴性乳腺癌细胞的增殖、侵袭和转移 [J]. 中国病理生理杂志, 2024, 40 (02): 244-254.
[2]Junting Zhang, Yiying Li, Jianchao Zhang, Lu Liu, Yuan Chen, Xusheng Yang, Xueyi Liao, Muhua He, Zihui Jia, Jun Fan, Jin-Song Bian, Xiaowei Nie. ADAR1 regulates vascular remodeling in hypoxic pulmonary hypertension through N1-methyladenosine modification of circCDK17. Acta Pharmaceutica Sinica B. 2023, 13(12): 4840-4855. //doi.org/10.1016/j.apsb.2023.07.006.
[3]Yanguan Guo, Jiaxin Tian, Yongjian Guo, Cong Wang, Congcong Chen, Songwang Cai, Wenliang Yu, Binghe Sun, Jin Yan, Zhonghua Li, Jun Fan, Qi Qi, Dongmei Zhang, Weilin Jin, Zichun Hua, Guo Chen. Oncogenic KRAS effector USP13 promotes metastasis in non-small cell lung cancer through deubiquitinating β-catenin. Cell Reports. Volume 42, Issue 12, 2023, 113511, //doi.org/10.1016/j.celrep.2023.113511.
[4]Lingtao Jin, Jaemoo Chun, Chaoyun Pan, Dan Li, Ruiting Lin, Gina N Alesi, Xu Wang, Hee-Bum Kang, Lina Song, Dongsheng Wang, Guojing Zhang, Jun Fan, Titus J. Boggon, Lu Zhou, Jeanne Kowalski, Cheng-Kui Qu, Conor E. Steuer, Georgia Z. Chen, Nabil F. Saba, Lawrence H. Boise, Taofeek K. Owonikoko, Fadlo R. Khuri, Kelly R. Magliocca, Dong M. Shin, Sagar Lonial, and Sumin Kang. (2018) MAST1 drives cisplatin resistance in human cancers by rewiring cRaf independent MEK activation. Cancer Cell (2018) Aug 13;34(2):315-330.e7. doi: 10.1016/j.ccell.2018.06.012. Epub 2018 Jul 19
[5]Zhao L, Fan J, Xia S, Pan Y, Liu S, Qian G, Qian Z, Kang HB, Arbiser JL, Pollack BP, Kudchadkar RR, Lawson DH, Rossi M, Abdel-Wahab O, Merghoub T, Khoury HJ, Khuri FR, Boise LH, Lonial S, Chen F, Chen J, Lin R. HMG-CoA synthase 1 is a synthetic lethal partner of BRAFV600E in human cancers. J Biol Chem. 2017 Jun 16;292(24):10142-10152. doi: 10.1074/jbc.M117.788778. Epub 2017 May 3. PubMed PMID: 28468827.
[6]Jin L, Chun J, Pan C, Alesi GN, Li D, Magliocca KR, Kang Y, Chen ZG, Shin DM, Khuri FR, Fan J, Kang S. Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis. Oncogene. 36, 3797-3806 (2017). doi: 10.1038/onc.2017.6. PubMed PMID: 28218905.
[7]Elf, S., Lin, R., Xia, S., Pan, Y., Shan, C., Wu, S., Lonial, S., Gaddh, M., Arellano, M.L., Khoury, H.J., Khuri, F.R., Lee, B.H., Boggon, T.J., Fan, J., and Chen, J. (2016) Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to anti-malarial agent dihydroartemisinin. Oncogene 36, 254-262. doi: 10.1038/onc.2016.196.
[8]Jin L, Li D, Alesi GN, Fan J, Kang HB, Lu Z, Boggon TJ, Jin P, Yi H, Wright ER, Duong D, Seyfried NT, Egnatchik R, DeBerardinis RJ, Magliocca KR, He C, Arellano ML, Khoury HJ, Shin DM, Khuri FR, Kang S. Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth. Cancer Cell. 2015 Feb 9;27(2):257-70. doi: 10.1016/j.ccell.2014.12.006. PubMed PMID: 25670081; PubMed Central PMCID: PMC4325424.
[9]Wang, J., Luo, C., Shan, C., Elf, S., Lu, Y., Zhou, Y., Wen, Y., Vinkenborg, J.L., Fan, J., Kang, H., Han, D., Karpus, J., Xie, Y., Ouyang, S., Luan, C., Zhang, N., Merkx, M., Liu, H., Chen, J., Jiang, H., He, C. (2015) Inhibition of human copper trafficking significantly attenuates tumor growth. Nature Chemistry 7, 968–979. doi:10.1038/nchem.2381.
[10]Li, D., Jin, L., Alesi, G.N., Kim, Y.M., Fan, J., Seo, J.H., Wang, D., Tucker, M., Gu, T.-L., Lee, B.-H., Taunton, J., Magliocca, K.R., Chen, Z.G., Shin, D.M., Khuri, F.R., Kang, S. The prometastatic ribosomal S6 kinase 2-cAMP response element-binding protein (RSK2-CREB) signaling pathway up-regulates the actin-binding protein fascin-1 to promote tumor metastasis. J. Biol. Chem. 2013 Nov 8;288(45) Epub 2013 Oct 1. doi: 10.1074/jbc.M113.500561.
[11]Jin, L., Li, D., Lee J.-S., Elf, S., Alesi, G.N., Fan, J., Kang, H.-B., Wang, D., Fu, H., Taunton, J., Boggon, T.J., Tucker, M., Gu, T.L., Chen, Z.G., Shin, D.M., Khuri F.R., and Kang, S. p90 RSK2 mediates antianoikis signals by both transcription-dependent and -independent mechanisms. Mol. Cell. Biol. 2013 Jul;33(13):2574-85. Epub 2013 Apr 22. doi: 10.1128/MCB.01677-12.
[12]Hitosugi, T., Zhou, L., Fan, J., Elf, S., Zhang, L., Xie, J., Wang, Y., Gu, T.-L., Aleckovic, M., LeRoy, G., Kang, Y., Kang, H.-B., Seo, J.H., Shan, C., Jin, P., Gong, W., Lonial, S., Arellano, M., Khoury, H.J., Chen, G.Z., Shin, D.M., Khuri, F.R., Boggon, T.J., Kang, S., He, C., and Chen, J. (2013) Y26 phosphorylation of PGAM1 provides a metabolic advantage to tumors by stabilizing the active conformation. Nature Communications 4, Article number:1790; doi:10.1038/ncomms2759
[13]Hitosugi, T., Zhou, L., Elf, S., Fan, J., Kang, H.-B., Seo, J.H., Shan, C., Dai, Q., Zhang, L., Xie, J., Gu, T.-L., Jin, P., Aleckovic, M., LeRoy, G., Kang, Y., Sudderth, J.A., DeBerardinis R.J., Luan, C., Chen, G.Z., Muller, S.M., Shin, D.M., Owonikoko, T.K., Lonial, S., Arellano, M., Khoury, H.J., Khuri, F.R., Lee, B.H., Ye, K., Boggon, T.J., Kang, S., He, C., and Chen, J. (2012) Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell. 2012 Nov 13;22(5):585-600. doi: 10.1016/j.ccr.2012.09.020. PMID: 23153533; PMCID: PMC3500524.
[14]Zhang, T., Wang,P., Ren, H.-G., Fan, J., Wang, G.-H. (2009) NGFI-B nuclear orphan receptor Nurr1 interacts with p53 and suppresses its transcriptional activity. Molecular Cancer Research Aug;7(8):1408-15. //doi.org/10.1158/1541-7786.MCR-08-0533.
1、《BIOCHEMISTRY》 （《生物化学》），清华大学出版社，2021高等教育“十三五”规划教材（英文版），全国高等医药院校规划教材；
2、《能量整合医学——线粒体ATP中西医基础与临床》，同济大学出版社，“十四五”时期国家重点出版物出版专项规划项目。
1、美国国立卫生研究院/美国国立癌症研究所，癌症杰出研究专项基金(SPORE头颈部肿瘤）培养项目奖 （P50CA128613），2012-2013，$10,000。研究项目：线粒体丙酮酸脱氢酶复合体在头颈部肿瘤代谢中作用机制研究（项目负责人）。
2、美国癌症协会，研究所研究基金奖，2016-2017，$30,000。研究项目：靶向乙酰辅酶A乙酰转移酶1（ACAT1)作为白血病治疗新策略的研究（项目负责人）。
3、温希普慈善晚会学者奖 2016-2017，$22,000。研究项目：靶向乙酰辅酶A乙酰转移酶1（ACAT1)治疗白血病研究（项目负责人）。
4、国家自然科学基金委 面上项目（主持），2020-2023。
5、广东省自然科学基金委 面上项目 （主持），2020-2022。
6、广东省自然科学基金委 面上项目 （主持），2023-2025。
7、广东省重大人才工程高层次人才引进项目（主持），2020。
8、苏州市医学会医学科技奖，2021。
9、暨南大学教育教学成果奖，二等奖，2021。
1、广东省生物化学与分子生物学学会，副理事长（2023- ）
2、广东省医学教育协会生殖与遗传专业委员会，副主任委员（2023-）
3、广东省药理学会肿瘤药理专业委员会常务委员（2019-）
4、中国抗癌协会肿瘤代谢专业委员会微环境专家组全国委员（2021-）
5、中国细胞生物学学会细胞代谢分会常务委员（2019-）
6、广东省药理学会内分泌代谢病药理专业委员会常务委员（2022-）
